Improve Your Process with Design of Experiments

Friday, February 2, 2018

Do you ever find yourself wishing you could understand more about the system you are working with, but are told you don’t have the time to do additional reactions?

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What design to use and when

Thursday, October 26, 2017

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Case Study 8

Friday, September 22, 2017

A case study showing how advanced DoE with PCA can be used at the start of a process to efficiently screen a large number of variables. In this case, PCA was applied to identify the catalyst, ligand and solvent requirements for a new catalytic reaction.

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Case Study 7

Friday, September 8, 2017

A cautionary tale about factor selection. The identification of significant factors is the difference between success and failure of a design. When a tried and tested experiment failed a user trial before the start of a new campaign, experimental design was used to uncover the problem.

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Factor Selection: completed fishbone and tips

Friday, August 25, 2017

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Factor Selection for a Screening Experiment

Monday, August 21, 2017

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Where can DoE fit in process development?

Thursday, August 3, 2017

Are you using DoE to its full potential?

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What is experimental design?

Thursday, July 20, 2017

The first post in the DoE demystified series introducing experimental design

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DoE Demystified

Monday, July 17, 2017

A series of posts going back to the basics of experimental design

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Case Study 6

Sunday, November 2, 2014

A Client observed a more than 10% of a high molecular weight impurity during the large-scale manufacture of an Active Pharmaceutical Ingredient (API). A Redox-Neutral Alcohol-Amine Coupling reaction was a potential alternative process replacing the SN2 displacement of a tosylate. The Redox Neutral coupling removes the Potential Genotoxic Impurity (PGI).

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