Improve Your Process with Design of Experiments
Do you ever find yourself wishing you could understand more about the system you are working with, but are told you don’t have the time to do additional reactions?
Read MoreWhat design to use and when
Case Study 8
A case study showing how advanced DoE with PCA can be used at the start of a process to efficiently screen a large number of variables. In this case, PCA was applied to identify the catalyst, ligand and solvent requirements for a new catalytic reaction.
Read MoreCase Study 7
A cautionary tale about factor selection. The identification of significant factors is the difference between success and failure of a design. When a tried and tested experiment failed a user trial before the start of a new campaign, experimental design was used to uncover the problem.
Read MoreFactor Selection: completed fishbone and tips
Factor Selection for a Screening Experiment
Where can DoE fit in process development?
Are you using DoE to its full potential?
Read MoreWhat is experimental design?
The first post in the DoE demystified series introducing experimental design
Read MoreDoE Demystified
A series of posts going back to the basics of experimental design
Read MoreCase Study 6
A Client observed a more than 10% of a high molecular weight impurity during the large-scale manufacture of an Active Pharmaceutical Ingredient (API). A Redox-Neutral Alcohol-Amine Coupling reaction was a potential alternative process replacing the SN2 displacement of a tosylate. The Redox Neutral coupling removes the Potential Genotoxic Impurity (PGI).
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