Short Course in Design of Experiments

Monday, October 5, 2015

Dr Paul Murray is running a short course in Design of Experiments (DoE) in conjunction with Scientific Update at the 3rd Winter Process Chemistry Conference at the University of Bath on the 16th December 2015.

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DoE training course for Chemists and Engineers - Hyderabad

Monday, October 5, 2015

I will be running a 3 day training course with Scientific Update on the use of Design of Experiments (DoE) @ Hotel Green Park in Hyderabad - 4th to 6th April 2016. DoE is a statistical tool which enables the efficient exploration of potential reaction parameters and their effect on a process. DoE is a fundamental aspect of Quality by Design. The course will introduce the DoE Process and how to use it to develop and understand chemical reactions and processes.

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DoE webinar

Friday, October 2, 2015

Dr Paul Murray gave a webinar on ‘An Introduction to DOE and its Use with Parallel Automation’ with Freeslate on Thursday 1st October.

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Scientific Update OPRD Conference Toronto

Friday, July 17, 2015

Dr Paul Murray, Paul Murray Catalysis Consulting, spoke at the Scientific Update Organic Process Research and Development conference in Toronto on ‘The application of advanced DoE for the efficient development of chemical processes’.

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DoE training course for Chemists and Engineers

Monday, January 26, 2015

I will be running a 3 day training course with Scientific Update on the use of Design of Experiments (DoE) @ the Sea Princess hotel in Mumbai - 13th to 15th April 2015. DoE is a statistical tool which enables the efficient exploration of potential reaction parameters and their effect on a process. DoE is a fundamental aspect of Quality by Design. The course will introduce the DoE Process and how to use it to develop and understand chemical reactions and processes.

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DoE training course for Chemists and Engineers

Monday, January 26, 2015

I will be running a 3 day training course with Scientific Update on the use of Design of Experiments (DoE) @ the Sea Princess hotel in Mumbai - 13th to 15th April 2015. DoE is a statistical tool which enables the efficient exploration of potential reaction parameters and their effect on a process. DoE is a fundamental aspect of Quality by Design. The course will introduce the DoE Process and how to use it to develop and understand chemical reactions and processes.

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Case Study 6

Sunday, November 2, 2014

A Client observed a more than 10% of a high molecular weight impurity during the large-scale manufacture of an Active Pharmaceutical Ingredient (API). A Redox-Neutral Alcohol-Amine Coupling reaction was a potential alternative process replacing the SN2 displacement of a tosylate. The Redox Neutral coupling removes the Potential Genotoxic Impurity (PGI).

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Scientific Update OPRD Conference

Friday, August 15, 2014

Dr Paul Murray, Paul Murray Catalysis Consulting, is speaking at the Scientific Update Organic Process Research and Development conference in Cologne on ‘The application of advanced DoE for the efficient development of chemical processes’.

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Intelligent Selection of Greener Solvents

Friday, August 1, 2014

Dr Janet Scott, University of Bath, present this week on the Intelligent Selection of Greener Solvents at the Gordon Green Chemistry Conference in Hong Kong. The talk was based on a collaborative project involving the use of Principal Component Analysis and Design of Experiments to efficiently identify suitable alternative solvents for chemical processes. The identification of alternative solvents for nucleophilic aromatic substitution was exemplified. The project was funded by the ACS GCI Pharmaceutical Roundtable.

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Case Study 5

Thursday, July 31, 2014

A Client observed a new impurity doing a large-scale manufacture. Through a detailed understanding of catalytic mechanism, the root cause of the impurity formation was identified immediately. The theory was rapidly proven by small scale experimentation and a modified production procedure adopted to prevent any reoccurrence of the problem.

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