Case Study 4

A leading pharmaceutical company needed to manufacture 60kg of an active pharmaceutical intermediate using a Suzuki reaction. The catalyst for this particular process would have cost £240,000 and the previous manufacture unexpectedly afforded < 50% yield. We identified alternative robust reaction conditions which enabled the significant reduction in the catalyst loading reducing the catalyst cost of this process by more than £140,000 while reliably achieving more than 95% isolated yield. This case study demonstrates how the new reaction conditions were identified.

Case Study 3

A pharmaceutical company needed to manufacture 5kg of an active pharmaceutical intermediate using a Suzuki reaction. The reaction was low yielding (< 45%) with a very high catalyst loading. We identified a new, high yielding and robust process for the rapid delivery of 5 kg of the required API intermediate in 1 week by kinetic evaluation for this Suzuki reaction leading to understanding of reaction mechanism. This case study demonstrates how.

Case Study 2

A leading pharmaceutical company needed to manufacture 80kg of an active pharmaceutical intermediate using a Buchwald Hartwig amination reaction. The catalyst for this particular process would have cost $300,000. We identified alternative catalyst systems which reduced the catalyst cost of this process by more than $280,000. This case study demonstrates how the new catalyst system was identified by combining Design of Experiments (DoE) and Principal Component Analysis (PCA) in the development of catalytic reactions.

Case Study 1

A leading pharmaceutical company needed to manufacture 100kg of an active pharmaceutical intermediate using a Suzuki reaction. The catalyst for this particular process would have cost $500,000. We identified alternative catalyst systems which reduced the catalyst cost of this process by more than $400,000.

Information Sheets

Paul Murray Catalysis Consulting is delighted to provide the following information data sheets:

Case Studies

Case Studies in DoE

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Biocatalysis Service Announcement

Paul Murray Catalysis Consulting Ltd is delighted to announce the addition of content to our website relating to our capabilities in Biocatalysis in collaboration with Dr Andy Wells.

Visiting Industrial Fellow at the Department of Chemistry, University of Bath

As a Visiting Industrial Fellow at the Centre for Sustainable Chemical Technologies I will be training and supporting the use of Design of Experiments and Principal Component Analysis.

Website Launch

Paul Murray Catalysis Consulting is delighted to announce the launch of its new website. Case studies in the use of DoE, PCA and Catalysis will follow shortly. If you would like to hear more about what Paul Murray Catalysis Consulting has to offer you please contact us on paul.murray@catalysisconsulting.co.uk.