Scientific Update OPRD Conference

Dr Paul Murray, Paul Murray Catalysis Consulting, is speaking at the Scientific Update Organic Process Research and Development conference in Cologne on ‘The application of advanced DoE for the efficient development of chemical processes’.

Intelligent Selection of Greener Solvents

Dr Janet Scott, University of Bath, present this week on the Intelligent Selection of Greener Solvents at the Gordon Green Chemistry Conference in Hong Kong. The talk was based on a collaborative project involving the use of Principal Component Analysis and Design of Experiments to efficiently identify suitable alternative solvents for chemical processes. The identification of alternative solvents for nucleophilic aromatic substitution was exemplified. The project was funded by the ACS GCI Pharmaceutical Roundtable.

Case Study 5

A Client observed a new impurity doing a large-scale manufacture. Through a detailed understanding of catalytic mechanism, the root cause of the impurity formation was identified immediately. The theory was rapidly proven by small scale experimentation and a modified production procedure adopted to prevent any reoccurrence of the problem.

Case Study 4

A leading pharmaceutical company needed to manufacture 60kg of an active pharmaceutical intermediate using a Suzuki reaction. The catalyst for this particular process would have cost £240,000 and the previous manufacture unexpectedly afforded < 50% yield. We identified alternative robust reaction conditions which enabled the significant reduction in the catalyst loading reducing the catalyst cost of this process by more than £140,000 while reliably achieving more than 95% isolated yield. This case study demonstrates how the new reaction conditions were identified.

Case Study 3

A pharmaceutical company needed to manufacture 5kg of an active pharmaceutical intermediate using a Suzuki reaction. The reaction was low yielding (< 45%) with a very high catalyst loading. We identified a new, high yielding and robust process for the rapid delivery of 5 kg of the required API intermediate in 1 week by kinetic evaluation for this Suzuki reaction leading to understanding of reaction mechanism. This case study demonstrates how.

Case Study 2

A leading pharmaceutical company needed to manufacture 80kg of an active pharmaceutical intermediate using a Buchwald Hartwig amination reaction. The catalyst for this particular process would have cost $300,000. We identified alternative catalyst systems which reduced the catalyst cost of this process by more than $280,000. This case study demonstrates how the new catalyst system was identified by combining Design of Experiments (DoE) and Principal Component Analysis (PCA) in the development of catalytic reactions.

Case Study 1

A leading pharmaceutical company needed to manufacture 100kg of an active pharmaceutical intermediate using a Suzuki reaction. The catalyst for this particular process would have cost $500,000. We identified alternative catalyst systems which reduced the catalyst cost of this process by more than $400,000.

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