Case Study 5
A Client observed a new impurity doing a large-scale manufacture. Through a detailed understanding of catalytic mechanism, the root cause of the impurity formation was identified immediately. The theory was rapidly proven by small scale experimentation and a modified production procedure adopted to prevent any reoccurrence of the problem.
A Miyaura borylation which had previously operated successfully for a 50kg delivery suddenly developed a significant new impurity which was difficult to remove from the product. Problem analysis linked with a deep mechanistic understanding of catalytic chemistry highlighted the likely cause of the impurity. The 1 day it took to resolve the problem allowed the successful manufacture of 100kg of the required boronic ester with a clear understanding of how to eliminate the problem for all future production runs.